Cancer is the second most fatal disease worldwide, with colon cancer being the third most prevalent and fatal form of cancer in several Western countries.The risk of acquisition of Book resistance to chemotherapy remains a significant hurdle in the management of various types of cancer, especially colon cancer.Therefore, it is essential to develop
Background: The gut-associated lymphoid tissue (GALT) is a major reservoir of HIV-1 established early in acute HIV-1 infection (AHI).Sampling tissue from GALT can provide information about viral reservoirs and immune responses but may be complicated during AHI for reasons such as high viral replication, CD4 T cell depletion and immune activation.Ri
Abstract Splicing factor 3B subunit 1 (SF3B1) is the largest component of SF3b protein complex which is involved in the pre-mRNA splicing mechanism.Somatic mutations of SF3B1 were shown to be associated with aberrant splicing, producing abnormal transcripts that drive cancer development and/or prognosis.In this study, we focus on the relationship b
In winter, barren-ground caribou obtain minerals from ice and soil licks.Between December and April we have seen DEODORANT SEXY SADIE caribou cratering on the surface of frozen lakes and licking the ice.Ice samples from eight licks on four lakes contained concentrations of calcium, magnesium, sodium, potassium, phosphorus, chloride and sulphate man